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Publication Type
Journal Article
Author, Analytic
Tulloch-Reid, M. K. ; Boyne, Michael S; Choo-Kang, Eric. G. ; Parkes, R. H. ; Wright-Pascoe, Rosemarie A. ; Barton, E. N. ; Wilks, Rainford J.; Palmer-Levy, M. L. ; Smikle, M. F.
Author Affiliation, Ana.
n/a
Article Title
Autoantibodies in Caribbean youth with diabetes mellitus
Medium Designator
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Connective Phrase
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Journal Title
Hum Antibodies
Translated Title
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Reprint Status
n/a
Date of Publication
2008
Volume ID
17
Issue ID
3-4
Page(s)
57-62
Language
eng
Connective Phrase
n/a
Location/URL
ISSN
1093-2607 (Print)
Notes
n/a
Abstract
The prevalence of diabetes and other autoantibodies in patients with recently diagnosed youth onset diabetes was evaluated. Fifty-seven patients (95% black, age 19 +/- 5 years, 36% male, diabetes duration 2.6 +/- 2.2 years) were clinically diagnosed as having type 1 (n = 35), type 2 (n = 13) and lipoatrophic diabetes (n = 3) while 6 remained untyped. GAD65 was the most common diabetes-associated autoantibody in patients with type 1A diabetes (12/17; 71%). The prevalence of any diabetes-associated autoantibodies decreased with diabetes duration (OR[95%CI]/yr after diagnosis 0.50[0.31,0.82]) and was not associated with age of onset, duration or gender. Rheumatoid factor (13/57; 23%), smooth muscle (6/57; 11%), gastric-parietal cell (5/57; 9%) and thyroid microsomal antibodies (5/57; 9%) were the most frequent non-diabetes associated autoantibodies and were more common in patients with type 1A diabetes. Only one patient had clinical autoimmune disease (hypothyroidism). Type 1A diabetes may constitute up to half the cases of newly diagnosed type 1 diabetes in Jamaican youth and is associated with a higher prevalence of other organ-specific autoantibodies.....
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Keywords