Gossell-Williams, Maxine D.; Simon, Oswald R.; West, M.E
Author Affiliation, Ana.
Department of Basic Medical Sciences
An alkaloidal (ALKS1) from Trophis racemosa lowers intraoccular pressure in dogs
Date of Publication
A 1.0% solution of ALKS1, an alkaloidal extract obtained from Trophis racemosa, produced a significant fall in intraocular pressure in the dog's eye (p<0.001). The fall was antagonized by atropine (p<0.0025), suggesting ALKS1 is acting through a muscarinic mode of action. Further purifcation of the extract is required to determine the actual compound producing this effect on the eye....