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Publication Type
Journal Article
Author, Analytic
Williams, Winston; Shah, Dipak J.; Williams, Eric
Author Affiliation, Ana.
n/a
Article Title
Renal histopathological changes in patients older than 10 years with hemoglobin Ss disease
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
The Internet Journal of Third World Medicine
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2007
Volume ID
6
Issue ID
1
Page(s)
n/a
Language
n/a
Connective Phrase
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Location/URL
http:; www.ispub.com/journal/the_internet_journal_of_third_world_medicine/volume_6_number_1_29/article_printable/renal_histopathological_changes_in_patients_older_than_10_years_with_hemoglobin_ss_disease.html
ISSN
n/a
Notes
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Abstract
Renal involvement in patients with hemoglobin SS disease is common. In children, tubular dysfunctions are the main abnormalities. Glomerular involvement occurs in young adults causing proteinuria in thirty percent of patients and chronic renal failure in four percent. A composite picture of mesangial hypercellularity, focal and segmental glomerulosclerosis, and occasionally mesangiocapillary like changes are seen in the glomeruli. A few patients may show immune complex glomerulonephritis, often superimposed on the changes described above. The glomerular changes seem to be hemodynamically mediated. Small short term studies show that angiotensin converting enzyme inhibitors may be beneficial in patients with proteinuria. Hemodialysis, peritoneal dialysis and renal transplantation should be offered to patients with end stage renal disease.....
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