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Publication Type
Journal Article
UWI Author(s)
Author, Analytic
Brady-West, Doreen C.
Author Affiliation, Ana.
n/a
Article Title
Treatment of Multiple Myeloma: Something Old, Something New
Medium Designator
n/a
Connective Phrase
n/a
Journal Title
Postgraduate Doctor Caribbean
Translated Title
n/a
Reprint Status
Refereed
Date of Publication
2006
Volume ID
22
Issue ID
3
Page(s)
71-75
Language
n/a
Connective Phrase
n/a
Location/URL
n/a
ISSN
n/a
Notes
n/a
Abstract
Multiple Myeloma is an incurable plasma cell malignancy characterised by anaemia, bone destruction and a monoclonal protein in the plasma and/or urine. Recent research has been directed at the mechanisms of the interaction between the neoplastic clone and the bone marrow microenvironment. This has led to trials of new agents for induction as well as for relapsed or refractory disease. Results indicate that immunomodulatory drugs may provide convenient alternatives to melphalan/prednisolone as first-line therapy. Proteasome inhibitors also show promise in combination with dexamethasone. Biphosphonates reduce the skeletal complications of the disease, and may contribute to apoptosis of the malignant clone.....
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Keywords