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Publication Type
Conference Proceedings
Author, Analytic
Boyne, M
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Current trends in type 2 diabetes mellitus treatment: the role of DPP4 inhibitors
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Proceedings Title
Caribbean Cardiac Society
Date of Meeting
July 14, 2013
Place of Meeting
Castries, St. Lucia.
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Abstract
Despite advances in diagnosis and treatment, type 2 diabetes mellitus (T2DM), overweight/obesity, cardiovascular disease, and their sequelae are major public health burdens worldwide. Type 2 diabetes mellitus (T2DM) is intimately connected to overweight/ obesity. It is a complex disorder of macronutrient metabolism that predisposes persons to, and is associated with, cardiovascular disease. The pathophysiology of T2DM involves the classical triumvirate of metabolic defects (involvement of the pancreatic b-cell, muscle, and liver), but there are other mechanisms including hyperglucagonaemia, accelerated gastric emptying, abnormal appetite and abnormalities of incretin biology. This has led to the development of incretin based therapies, i.e. glucagon-like peptideľ1 (GLP-1) receptor agonists and dipeptidyl peptidaseľ4 (DPP-4) inhibitors. They inhibit glucagon release, potentiate insulin secretion, reduce hepatic glucose output, and promote satiety through peripheral and central mechanisms. These therapies, administered as monotherapy or in combination with other oral antidiabetic agents, have beneficial effects on b-cell function, glycaemia, body weight, and may have potential effects on other markers of cardiovascular risk. DPP-4 inhibitors are particularly suitable for the elderly or patients with macrovascular complications because of their excellent tolerability profiles.....
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