Dilworth, Lowell L; Omoruyi, Felix O; Asemota, Helen N.
Author Affiliation, Ana.
Effects of IP6 and Sweet Potato (Ipomoea batatas) Phytate on Serum, Liver and Faecal Lipids in Rats
International Journal of Food Science and Nutrition Engineering
Date of Publication
Dyslipidemia is associated with coronary heart disease. It is known that phytate supplementation reduceshepatic triglyceride and cholesterol concentrations in rats. Here, we investigated the effects of sweet potato phytate extract or IP6 on liver, serum and faecal lipid levels as well as intestinal lipase activity in rats fed zinc deficient of zinc sufficient diets. There were significant increases in intestinal lipase activity in the test group fed diets supplemented with sweet potato phytate extract only, compared to other groups. Conversely, faecal triglyceride concentrations were significantly reduced in this group compared to other test groups. Faecal cholesterol output was significantly increased in rats fed diets supplemented with phytate extract only compared to other groups. Total serum lipids did not vary among the groups, however, significantincreases in both serum triglyceride and HDL concentrations were observed in test animals compared to control groups. Liver phospholipid concentrations were found to be significantly higher in animals that consumed zinc supplemented diets compared to those on zinc deficient diets. Phytates may induce hypolipidemia by upregulating intestinal lipase activity resulting in increased faecal cholesterol output and reduced serum lipid levels. Increased serum HDL concentration in rats fed phytate suggests that this supplement may possess cardioprotective properties.....